Marie of Lusignan (1273 – Tortosa, April 1319) was a daughter of Hugh III of Cyprus and his wife Isabella of Ibelin.

Marie remained unmarried for many years; she was recorded as having been present in her brother Amalric's court in 1310.

She was however eventually betrothed to James II of Aragon in 1315, who had been married twice before and was father to ten legitimate children.

As Marie was heiress to Cyprus, James considered a matrimonial union with her to be politically advantageous.

They married by proxy at Santa Sophia, Nicosia on 15 June 1315 and in person at Girona on 27 November 1315.