Marie of Savoy, Countess of Saint-Pol, de Brienne, de Ligny, and Conversano (20 March 1448) was the second wife of Louis de Luxembourg, Count of Saint-Pol, Constable of France.
She was a younger daughter of Louis, Duke of Savoy and Anne de Lusignan, Princess of Cyprus, one of nineteen children.
Marie was born on 20 March 1448, one of the 19 children of Louis, Duke of Savoy and Anne de Lusignan of Cyprus.
In 1454 at the age of six, she was betrothed to Filippo Maria Sforza (1448–1492), the son of Francesco I Sforza, Duke of Milan, and Bianca Maria Visconti.
For reasons unknown, the betrothal was annulled, and he married instead his cousin, Costanza Sforza.