Marine Tactical Air Command Squadron 48 (MTACS-48) is a reserve aviation command and control unit of the United States Marine Corps based at Naval Station Great Lakes, Illinois.

The squadron provides personnel and equipment for establishing the 4th Marine Aircraft Wings tactical headquarters and command post.

It currently falls under the command of Marine Air Control Group 48 and is the last active MTACS in the Marine Corps due to reorganization as part of Force Design 2030.

Provide equipment, maintenance, and operations for the Tactical Air Command Center (TACC) of the Aviation Combat Element (ACE), as a component of the Marine Air-Ground Task Force (MAGTF).

The squadron relocated to Highwood, Illinois in 1995 and again in 2001 to their current location at Naval Station Great Lakes.