Mario Addison (born September 6, 1987) is an American football defensive end who is a free agent.

After suffering a broken hand on his throwing arm, he changed positions to defensive end.

After redshirting his first year in 2008, he began seeing playing time in 2009 as a reserve player at the defensive end position.

Addison began receiving attention from various NFL teams for his performance that year, but was never drafted.

He was cut by the Bears on November 21, 2011, to free up space on the 53-man roster for veteran players to cover the injuries picked up by long snapper Patrick Mannelly and quarterback Jay Cutler in the previous day's 31–20 victory over the San Diego Chargers.

[13] On February 26, 2017, Addison signed a three-year contract extension with the Panthers after leading the team with 9.5 sacks in 2016.

[14] In Week 3 of the 2019 season against the Arizona Cardinals, Addison sacked rookie quarterback Kyler Murray three times in the 38–20 win.

In the Divisional Round of the playoffs against the Baltimore Ravens, Addison recorded one sack on Tyler Huntley during the 17–3 win.

[citation needed] His brother, Gjamal Antonio Rodriqcus, was shot and killed on October 30, 2019.