The Cardinals finished tied with the Chicago Bears for the last Wild Card spot, but lost the tiebreaker.

The 2020 season featured the Hail Murray, as during Week 10 on November 15, trailing the Buffalo Bills 30–26 with eleven seconds remaining in the fourth quarter, Kyler Murray completed a 43-yard Hail Mary touchdown pass to DeAndre Hopkins with one second remaining to lift the Cardinals over the Bills in a miraculous 32–30 victory.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve The Cardinals' preseason schedule was announced on May 7, but was later cancelled due to the COVID-19 pandemic.

In the final seconds of game, Kyler Murray threw a game winning touchdown pass to wide receiver DeAndre Hopkins with two seconds left after he leaped over three defenders in the end zone to make the catch.

The play came at the end of a game in which the Cardinals rallied from a 23–9 deficit early in the third quarter, and from a 30–26 deficit after Bills quarterback Josh Allen threw a touchdown pass to wide receiver Stefon Diggs with less than 40 seconds left.

This was the first time a successful game-winning Hail Mary catch in the fourth quarter was made since Aaron Rodgers threw one in a 2015 game against the Detroit Lions.