Mario "Lupo" Cantaluppi (born 11 April 1974) is a Swiss former professional footballer who played as a defender or midfielder.

[1] Born in Schlieren, Switzerland, Mario Cantaluppi started his professional career with Grasshopper Club Zürich in 1990 and won the 1990–91 Nationaliga A in his debut season.

In 1993, he dropped down a division to sign for FC Basel who were playing in the Nationalliga B at the time.

[3] During that season, his team mates were the likes of Swiss international goalkeeper Stefan Huber, defenders Massimo Ceccaroni, Marco Walker and Samir Tabakovic, the midfielders Reto Baumgartner, Martin Jeitziner, Admir Smajić and Ørjan Berg and the Swiss international strikers Dario Zuffi and Philippe Hertig.

He helped Switzerland qualify for UEFA Euro 2004 but was left out of the final squad for the tournament after falling out with national coach Köbi Kuhn.