Mario Caserini (26 February 1874 – 17 November 1920) was an Italian film director, as well as an actor, screenwriter, and early pioneer of film making in the early portion of the 20th century.

Caserini was born in Rome, Italy, and was married to early 20th-century Italian actress Maria Caserini.

His 1906 film Otello is believed to be the earliest film adaptation of the William Shakespeare play Othello.

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