Mario Prestifilippo (Italian pronunciation: [ˈmaːrjo prestifiˈlippo] 7 December 1958 – 29 September 1987) was a member of the Sicilian Mafia.
He played a significant role as a hitman in the Second Mafia War of the early 1980s orchestrated by Salvatore Riina.
He was a member of the death squad of the Corleonesi clan that was commanded by Greco and took part in many significant murders during the war from 1981–1982 including the Circonvallazione massacre on 16 June 1982.
Prestifilippo was shot to death by two killers armed with a shotgun and an AK-47 as he sped through the streets of Bagheria on 29 September 1987 on a motorbike, moving from one hiding place to another.
At the time of his death, he was a fugitive, suspected of dozens of murders, and was being tried in absentia at the Maxi Trial.