Wyeth was among a group of architects considered the "Big Five," along with John L. Volk, Addison Mizner, Maurice Fatio, and Howard Major, who defined Palm Beach style in the early twentieth century.

His grandfather J. Marion Sims founded the first Women's Hospital in the U.S. in 1855 (it is now part of Mount Sinai Morningside).

[4] Wyeth had over 700 commissions, many of which in Palm Beach, including Mar-a-Lago (1923-1927 with Joseph Urban).

Other notable commissions include the Norton Museum of Art (1941) in West Palm Beach, the Florida Governors Mansion in Tallahassee, and Shangri La, Doris Duke’s house in Honolulu, Hawaii.

[5] In 1993, Wyeth's archives were donated to the Preservation Foundation of Palm Beach by architect Sidney Neil.