Cabrini Medical Center of New York City was created in 1973 by a merger of two Manhattan hospitals.

[6] In 1913 it expanded again, acquiring "annex" facilities vacated by the New York Polyclinic Hospital at 214–218 East 34th Street.

[11] In the 1980s, it was one of the earliest hospitals to develop expertise for the AIDS epidemic that became a leading cause of death in its neighborhood.

"[13] The center closed permanently on March 16, 2008, due to financial difficulties that resulted in patients and staff seeking other health care and employment.

[18][19] The development of the former Cabrini site has led to members of the City Council and NYS Assembly exploring limitations on what can be done with Mount Sinai Beth Israel upon its closure and sale.