Mariovo and Prilep rebellion (Macedonian: Мариовско-Прилепска буна) was the first recorded Slavonic Christian uprising in Ottoman North Macedonia,[1] that took place in 1564–65.

The uprising began in Mariovo, a mountainous region south of Prilep, where local peasants, supported by the lower clergy and village elders, took up arms in resistance.

It quickly spread to Prilep and the surrounding villages as the rebels seized control of certain areas and expelled Ottoman officials.

Stojan Pejo, and 5. priest Jakov from Staravina [3] The leaders were either executed or exiled, and harsh reprisals followed against the local population.

The revolt was inspired by Austrian victories against the Ottomans and fueled by hopes that the Habsburgs would liberate Macedonia, especially after they captured Skopje in 1689, though they later retreated.

Instead, records suggest the occurrence of another, smaller-scale peasant uprising of a local nature, which, in terms of intensity and mass participation, cannot be compared to the earlier revolt.

However, Dr. A. Stojanovski, based on Ottoman documents, refutes this claim, arguing that while Mariovo did not possess true "land autonomy," the existence of a form of limited village self-government remains a possibility.