She entered a choir and dance group named Los joselitos del cante belonging to the Sección Femenina's national organization Coros y Danzas [es].

She received dance, acting, and declamation classes taught by the best teachers, with the idea of making her the star of children's and youth cinema.

In her first film, A Ray of Light (Luis Lucia, 1960), a huge merchandising campaign was organized around the new star, with books, dolls, cards, and all kinds of objects with the image of the girl.

Each film premiere included a tour of Spain and Hispanic countries to promote it, with all kinds of events creating tumults and crowds at the airports.

In 1963 she starred in Marisol rumbo a Río, where she played twins (similar to Hayley Mills in The Parent Trap) and sang "Bossanova junto a ti", "Muchachita", "¡Oh, Tony!

She appeared in Solos los dos [es] (1968), where she sang "La nieve" (her most popular song in South America, composed by Juan Pardo and Rocío Dúrcal's husband, Júnior).

Marisol received the Best Actress Award at the Karlovy Vary International Film Festival for her role in Los días del pasado (1978).

In the wake of the Me Too movement, the claims Marisol made to Francisco Umbral and Interviú in the late 1970s about the sexual abuse she underwent as a child star resurfaced in Spanish Vanity Fair in 2018.