Her research covers retrieval, user engagement, databases, digital cultural heritage, and data engineering.

Agosti obtained the "Laurea" degree in Statistics in 1975 (summa cum laude) with a research thesis on algorithms for automatic classification and worked as Online catalogue designer at the Historical Archive of Contemporary Arts (ASAC) of Biennale di Venezia until 1976.

Agosti is a researcher and professor, covering areas such as information retrieval, user engagement, databases, digital cultural heritage, and data engineering.

She worked as Online catalogue designer at the Historical Archive of Contemporary Arts (ASAC) of Biennale di Venezia until 1976.

With Costantino Thanos and other experts she started the Italian Research Conference on Digital Library Systems (IRCDL[4]).