[1][2] He is best known for his work on the film Cubby and his recurring role as "Zack" on the Apple TV+ series Little Voice.

[5] He began his film career as a co-writer on The Death and Life of Marsha P.

[6] He is a playwright and author of The Rock and The Ripe: The Bullied and Bruised Gay Youth of America.

[7] In 2019, Blane wrote and co-directed the feature film Cubby, along with Ben Mankoff, about a babysitter and a young boy trying to discover their place in New York City.

[9][10] His short film, Ghost Bike, starring Tamara Tunie, Mike Doyle and Carly Blane, was released on Apple in 2024.