DiFelice also played part of the 2001 season for Carolina, while also pitching for the Triple-A Colorado Springs Sky Sox.

In 2005, DiFelice pitched for the Washington Nationals with their Triple-A New Orleans Zephyrs and the independent Atlantic League's Somerset Patriots.

DiFelice returned to affiliated baseball in 2007, playing for the Milwaukee Brewers' Double-A Huntsville Stars, and then their Triple-A Nashville Sounds.

After starting the 2008 season in Nashville, posting a 3–0 record with a 3.91 ERA, DiFelice's contract was purchased by Milwaukee on May 15, and he made his major league debut three days later, May 18.

He made it back to the major leagues only to have his shoulder give out again, requiring a 3rd surgery and ending his 2011 season.

When word spread that DiFelice cut hair, his teammates began making appointments for haircuts in the clubhouse.