He is best known for his roles as Francis Buxton in Pee-wee's Big Adventure (1985), Chubby in the Teen Wolf film series, Ozzie Jones in the Leprechaun film series, and for his portrayal of serial killer John Wayne Gacy in Gacy (2003).
[3][4] His mainstream visibility grew with supporting roles in The Naked Gun: From the Files of Police Squad!
[5] Holton has been equally prolific in television, performing in episodes of The Young and the Restless, Seinfeld, MacGyver, Sledge Hammer!, Tim and Eric Awesome Show, Great Job!, Star Trek: Deep Space Nine, NCIS, and NYPD Blue.
Following his cameo appearance in The Adventures of Rocky and Bullwinkle (2000), Holton refocused his attention on independent film and television projects.
He returned to film acting in the made-for-television movie Leprechaun Returns (2018), a direct sequel to the original cult comedy horror Leprechaun (1993), reprising the role of Ozzie.