Poznansky returned to Canada in 1976, taking a position as associate professor of physiology at the University of Alberta in Edmonton.

[6] In 1984, Poznansky moved on to become the associate dean of medicine at the University of Alberta in Edmonton, a position he held for 9 years.

The company was able to bring a candidate drug to the start of Phase II and raised $20 million to support future research efforts.

[9] The rapid physical and staffing growth of the Institute led to major financial issues in 2007, necessitating the take-over of the Robarts by the University of Western Ontario.

He also aided the Thunder Bay Regional Institute in attracting not only some of the "most respected health research minds in Canada"[12] but those from around the globe.

[16] On August 1, 2017, Poznansky joined Spindle, a strategic consulting firm that focuses on life and health sciences innovation, as a member of its Senior Advisory Group.

On September 22, 2020, ECW Press released Saved By Science: The Hope and Promise of Synthetic Biology.

[19] Kirkus Reviews said the book was "energetic and optimistic" and “shows how synthetic biology can be used to contend with major issues involving health, food, and the environment.

[28] Poznansky lectures on subjects related to the biopharmaceutical industry and research and administration and funding, including technology transfer.

[31] Dr. Poznansky presented at a session at the 2019 Canadian Science Conference on: Policy Lessons in the Age of Technological Disruption.