Mark Duane Karcher (born November 22, 1978) is a retired American professional basketball player who was selected by the Philadelphia 76ers in the 2nd round (48th pick) in the 2000 NBA draft.

Ineligible as a freshman in 1997–98, Karcher played two years of college basketball as a guard/forward with Temple University from 1998 to 2000 before leaving early to enter the 2000 NBA draft.

Karcher participated in training camp with the Philadelphia 76ers, but never played for them in a regular season game.

He was selected with the 59th pick in the 2001 NBA D-League draft by the Greenville Groove, and would also play for the Richmond Rhythm of the International Basketball League that same year.

This biographical article relating to a United States basketball player, coach, or other figure born in the 1970s is a stub.