He is best known for his appearances on the CBC Television sitcom Mr. D, playing Simon Hunt, the Xavier Academy science teacher, and his work with Picnicface.

[1] The troupe has produced several successful viral videos, is featured on Funny or Die,[2] and stars in the films Roller Town[3] and Room for Rent.

Little is also the co-star of CTV's Space Riders: Division Earth, a Power Rangers-themed web series that released its first season in 2014.

Little portrayed Xavier Academy Science teacher Simon Hunt on the CBC Television sitcom Mr. D from 2012 until the show’s end in 2018, appearing in all 8 seasons.

[6] Little was subsequently hired to voice a drink ad inspired by the film Idiocracy called "Brawndo: The Thirst Mutilator".