Little played four years in the Rangers minor league system, getting as high as Triple-A, before being traded on August 9, 1998, along with Darren Oliver and Fernando Tatís to the St. Louis Cardinals for Royce Clayton and Todd Stottlemyre.

[1] Little was assigned to the Cardinals Triple-A affiliate, the Memphis Redbirds, before making his major league debut on September 12, 1998.

2002 saw Little get the most at bats in a single season of his entire career with 130; he did this playing for the Rockies, New York Mets, and Arizona Diamondbacks.

He was acquired by the Mets along with John Thomson for Jay Payton, Mark Corey, and Robert Stratton.

He played for the Marlins Triple-A affiliate, the Albuquerque Isotopes, during the 2005 and 2006 seasons, before retiring from Major League Baseball.