Mark Lee Mayer FRS[1][3] is scientist emeritus at the National Institutes of Health (NIH).

His research investigates glutamate receptor ion channels, the major mediators of excitatory synapses in the brain.

[1] Major findings include discovery of the block of NMDA receptors by extracellular Mg and their high Ca permeability; analysis of the permeation and block of Ca permeable AMPA and kainate receptors by cytoplasmic polyamines; and structural studies on ligand binding, allosteric modulation, and gating using X-ray diffraction and cryoelectron microscopy.

Mayer's research interests are in Biophysics, Glutamate receptors, Structural biology and Ion channels.

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