[1] Musen's research focuses on open science, data stewardship, intelligent systems, and biomedical decision support.
[2][3] Since the late 1980s, Musen has led the development of Protégé, which is currently the most "widely used domain-independent, freely available, platform-independent technology for developing and managing terminologies, ontologies, and knowledge bases" in a range of application domains.
Musen completed his residency in internal medicine at Stanford University Medical Center in 1983.
After residency, he completed a doctoral degree in Medical Information Sciences at Stanford in 1988.
He was appointed Director of the Stanford Center for Biomedical Informatics Research in 1993 and promoted to Professor of Medicine in 2002.