His father played gridiron in high school and Brad's brother, Kyle, helped lead the football team for four years at the University of Guelph.

[4] He attended Grand River Collegiate Institute for high school, during which he competitively played volleyball, basketball, badminton, and track and field.

[9] Following the 2009–10 season, Scheifele's playing rights were traded by the Spirit (along with a second-round choice in 2013) to the Barrie Colts in exchange for goaltender Mavric Parks.

[18] On October 3, 2011, the Jets announced that they had signed Scheifele to an entry-level contract,[19] and that he would start the season on Winnipeg's NHL roster.

[1] During the 2014–15 offseason, Scheifele used DNA testing to increase his muscle mass and he arrived at the Jets' training camp 11 pounds (5.0 kg) heavier than the previous season.

[37] During the second half of the season, he scored his first NHL hat-trick in a contest against the Montreal Canadiens on March 5, 2016, thus ending the teams' three-game losing streak.

[38] Scheifele finished the regular season with a career high 61 points in 71 games as the Jets qualified for the 2016 Stanley Cup playoffs.

[40] Jets head coach Paul Maurice praised his leadership ability, saying "Mark Scheifele is going to be the captain of this hockey team at some point in his career for sure."

[42] Following his break-out season, Scheifele acknowledged there was increased pressure on the team to qualify for the Stanley Cup playoffs after missing it the past two years.

By the time he played Game 3 of the Western Conference Final against the Vegas Golden Knights, he had recorded 14 goals in total, 11 of which were on the road.

The previous record was held by Joe Mullen and Sidney Crosby, who scored 10 times on the road during Stanley Cup runs for the Calgary Flames and Pittsburgh Penguins, respectively.

[45] Scheifele also tied Washington Capitals captain Alexander Ovechkin for the NHL lead in road playoff goals during the past two postseasons.

On November 10, Scheifele recorded his ninth career overtime goal, tying Ilya Kovalchuk for the most in Jets/Atlanta Thrashers history.

[57] At the end of December, Scheifele and teammate Connor Hellebuyck were selected for the 2020 National Hockey League All-Star Game.

[58] Shortly following his selection, Scheifele was recognized as the NHL's Second Star of the Week ending on January 6 after recording three multi-point games to tie for the League lead in scoring.

[59] Upon returning from the All-Star Break, Scheifele went 12 games without scoring a goal before recording his third career NHL hat-trick on February 20 against the Ottawa Senators.

[60] When the league officially paused the season in March due to the COVID-19 pandemic, Scheifele had accumulated 29 goals and 44 assists for 73 points through 71 games.

[67] During training camp, Scheifele was paired with Ehlers and Wheeler which diverted from his previous left-wing partner Kyle Connor.

[70] Scheifele finished the 2020–21 regular season with 21 goals and 42 assists for 63 points through 56 games as the Jets met with the Edmonton Oilers in the First Round of the Stanley Cup playoffs.

[78] As both Scheifele and the Jets struggled to win games, head coach Paul Maurice was replaced with Dave Lowry on December 17.

[81] The Jets were eliminated from playoff contention on April 20, 2022, after the Vegas Golden Knights defeated the Washington Capitals 4–3 in overtime.

[86] While the team suffered setbacks due to injuries, Scheifele and Dubois continued to lead the top two lines and collect points.

[87] His sixth hat-trick came in a 6–5 loss to the Vegas Golden Knights on December 13[88] while his seventh came at the end of the month in a win over the Vancouver Canucks.

[95] During his rookie season with the Jets, Scheifele played for the senior Canadian team at the 2014 IIHF World Championship in Minsk.

[96] He was later named to Team Canada's 2016 IIHF World Championship roster, held in Moscow and Saint Petersburg, where he won the gold medal.

[97] Later that year, Scheifele represented Team North America at the 2016 World Cup of Hockey,[98] playing on the top line alongside Auston Matthews and Connor McDavid.

[40] In 2019, Scheifele announced his decision to skip the 2019 IIHF World Championship after the Jets were eliminated from the Stanley Cup playoffs.

[101] Once making the NHL full-time, he earned numerous praises from teammates and opponents, including former Toronto Maple Leafs head coach Mike Babcock who called him "one of the best centres in the league.

"[102] Scheifele is a practising Christian and has gathered with teammates Adam Lowry, Josh Morrissey, and formerly Tucker Poolman to pray and talk.