He played college football for the Minnesota Golden Gophers and was selected by the St. Louis Rams in the seventh round of the 2006 NFL draft.
Setterstrom earned All-State, All-Metro, and All-Conference honors as senior at Northfield High School in Minnesota, where he was a two-way lineman who totaled 127 tackles, six sacks, five forced fumbles, and six fumble recoveries over career for Northfield Raiders.
and a Fourth-team All-America Freshman selection by The Sporting News and Big Ten All-Freshman Team.
In his rookie season with St. Louis, Setterstrom appeared in seven games, starting six of those at left guard.
Also he missed all of the 2008 season with knee injuries but was re-signed by the Rams to one-year deal during the 2009 off-season.