The Mark Twain Birthplace State Historic Site is a publicly owned property in Florida, Missouri, maintained by the Missouri Department of Natural Resources, that preserves the cabin where the author Samuel Langhorne Clemens was born in 1835.

[5] The cabin is protected within a modern museum building that also includes a public reading room, several of Twain's first editions, a handwritten manuscript of his 1876 novel The Adventures of Tom Sawyer, and furnishings from Twain's Connecticut home.

The cabin was listed on the National Register of Historic Places in 1969.

[6] Samuel Clemens, later known by the pen name Mark Twain, was born in the two-room house on November 30, 1835.

[8] Clemens spent his first four years here until the family moved to a two-story clapboard house, now memorialized as the Mark Twain Boyhood Home & Museum in Hannibal, Missouri, in 1839.