A short portion of the road continues west from Cobbs Creek Parkway (63rd Street) to Delaware County, adjacent to Philadelphia.

Long before the city was laid out or settled, Philadelphia's founder, William Penn, had planned that markets would be held regularly on the 100-foot (30 m) wide High Street.

Later, additional covered sheds appeared west of Center Square as the city expanded westward.

The road's new name was made official by an ordinance in 1858, coincidentally just a year before the market sheds were ordered removed.

The mansion of Robert Morris, financier of the American Revolution, was located near 6th and Market Streets.

The house was located on the site of the northern part of the present-day Liberty Bell Center.

[6] East of the intersection of Front and Market Streets is an entrance to Penn's Landing on the Delaware River.

Adjacent to Independence Mall is the National Museum of American Jewish History, which relocated to that location in 2010 and occupies the spot once held by CBS 3 and KYW Newsradio 1060.

One Liberty Place, formerly Philadelphia's tallest building, is located at the southeast corner of 17th and Market Streets.

June 5th Memorial Park is located at 22nd and Market Street in remembrance of the six people who lost their lives as a result of the collapse of a Salvation Army Thrift Store.

As a result, the section of Market Street along University City is also signed "Avenue of Technology".