[2] Markleton derived its present name from the paper company of Cyrus P. Markle & Sons of West Newton in nearby Westmoreland County.

The Markle buildings and land were purchased by William J. Hitchman of Mount Pleasant, Pennsylvania, in late 1886 for the purpose of establishing a combination vacation resort/health sanatorium.

[12] Dr. M. Annie Howe-Anthony, a graduate of the Woman's Medical College of Baltimore, spent a year at the Markleton Sanatorium, during which she was the only female physician present.

Asked about her experience there later, she said, "The year at Markleton was an interesting and happy one, for there a woman physician was always honored and treated with the greatest respect.

[16] According to the Baltimore & Ohio Railroad's Resorts and Springs guide for Summer 1905, the sanitarium had a capacity for 150 guests and charged rates from $2.50 per day to $60.00 per month.

[19][20] After the United States entered World War I, the federal government operated the former sanatorium building as U.S. Army General Hospital No.

[22] The hospital was designated by Army Surgeon General Merritte W. Ireland as specializing in the treatment of soldiers suffering from tuberculosis.

[39][40] Some of the nurses who served at the hospital included Ila Broadus;[41] Agnes Julia Hasenfuss, Pauline Wilson, Laura Anderton, Myra F. Rhodes, Edith M. Mitchell, & Miriam A. Wilson;[42] Estella M. Campbell, Mary Homan, & E. Lorraine Green;[43] Josephine Amada Grima Comstock;[44] Edith Head, Margaret A. Pedersen, Sara A. Carr, & Pluma M. Geesey;[45] Anna E. Flood, Urma Klahr Turner Elswick, Grace Louise Sirine Royden, & Grace Sechler;[46] Ruth E. Anderson;[47] Cora L. Field;[48] Florence Dawson & Irene G. Clark;[49] Eugenia Mary Hitchcock, Matilda Clifton, Marie O'Brien, & Helen J. Woodbridge;[50] Flora Hauster, Rava Hughes Kelly, Jennie Wilson Lyons, & Helen W. Ross;[51] and Anna K.

[57] Eventually, without the flow of people brought in by the sanatorium / hospital, the Baltimore & Ohio Railroad closed its ticket agency at Markleton on Jan. 9, 1924.

[58] Several railroad tunnels were built just downstream from Markleton as the Casselman River flows southwest towards Fort Hill and Confluence.

[59][60] A fire broke out in October 1879, destroying the original tunnel and necessitating the construction of a rail line following the river around the point.

[61] A view of the nearby Shoo Fly Tunnel appeared in a collection of photographs from along the Baltimore and Ohio Railroad's rail lines that was published in book form in 1872 and digitized by the DeGolyer Library, Southern Methodist University.

It lies along Markleton School Road, to the east of Pennsylvania Route 281, south of the village of Kingwood and north of Fort Hill.