He achieved several high offices - chamberlain to Archduke Ernest of Austria, Kammerpräsident, member of the kurbayrische (Bavarian) council, Pfleger (reeve) in the Landshut, and city-pfleger in Augsburg.
Similarly, on his father's death, as eldest son Markus led the newly founded Marx Fugger and Brothers Firm (Firma Marx Fugger und Gebrüder) for 30 years.
He was interested in church history, acted as a patron to artists and collected books and antiquities, taking on Nikolaus Juvenel as a portrait painter in Augsburg.
In 1557, he married Gräfin (countess) Sibylla von Eberstein (1531–1589), allying the Fugger family with a number of noble families in south-west Germany - the Margraves of Baden-Sponheim, the Counts of Hanau-Lichtenberg and the Counts of Eberstein.
The marriage produced 13 children (8 girls and 5 boys), though the male-line descent from Markus died out in 1671.