Markville S.S. is located in an area that was developed by the Melchior Quantz family of Germany in the city of Markham who came to North America with William Berczy.

As of 2009, teachers Adrienne Chong, Rob Cotey and Mark Melnyk have received the Prime Minister's Awards for Teaching Excellence.

[5] Markville offers music courses for grades 9 through 12 including: In the 2018/2019 year, Markville Secondary School ranked number #2 among high/secondary schools in Ontario, and ranked #5 for the 5 year period from the school year ending in 2014 to 2019,[2] based on the Fraser Ranking System (from Simon Fraser University in British Columbia).

Through this program, peer tutors receive volunteer hours which are required in order to graduate from high school.

Previously, Markham gifted students who resided west of McCowan Road attended Markville Secondary School while those living on the East of McCowan Road attended Markham District High School.