During his high school career, he compiled 281 career tackles, nineteen tackles for losses, three quarterback sacks, seven forced fumbles, three recovered fumbles and eighteen interceptions, including four touchdown returns.

Jackson earned all-state honors, was the Pennsylvania high school player of the year and picked for the USA Today and Prep Football Report All-American teams.

Jackson finished his career as the second all-time leader among Michigan players in pass breakups.

On January 21, 2007, Jackson intercepted New England Patriots quarterback Tom Brady with 18 seconds left in the fourth quarter of the AFC Championship Game to seal the Colts' 38–34 victory and send them to Super Bowl XLI against the Chicago Bears, which they subsequently won.

Sports delivered an update on his status on June 25 saying that he "looks to be making strong progress from midseason knee surgery.

[10] Key His older brother Elmarko Jackson was a running back for Temple University.

He was involved in an incident which made headlines in 2000 when he was stabbed several times on campus after an argument with another student.

A 26-year-old man accused Jackson of striking him in the right eye with a bottle on June 1, requiring 17 stitches, in Ann Arbor, Michigan.