He was selected by the Denver Broncos in the second round of the 1999 NFL draft, and also played for the Indianapolis Colts (with whom he won Super Bowl XLI) and Philadelphia Eagles.
He started in 41 of 44 career games, and holds the Red Raiders' team record with 24.5 sacks and 47 tackles for loss.
After the Colts won Super Bowl XLI, the team terminated his contract on March 1, 2007, due to the severity of his injury.
His signing allowed the Eagles to trade defensive tackle Darwin Walker and a conditional draft pick in 2008 to the Buffalo Bills for linebacker Takeo Spikes and quarterback Kelly Holcomb.
Due to his successful play and return from his severe injuries, Reagor was named as the Philadelphia Eagles recipient for the 2007 Ed Block Courage Award.