Meltzer, alongside Kathleen Antonelli, Jean Jennings Bartik, Frances Elizabeth Holberton, Frances Spence and Ruth Teitelbaum, were the original six programmers of ENIAC,[3] a project that originally began in secret at the Moore School of Electrical Engineering at the University of Pennsylvania in 1943.

[4] ENIAC was a huge machine full of black panels and switches, containing 17,468 vacuum tubes, 7200 crystal diodes, 1500 relays, 70000 resistors, 10000 capacitors and approximately 5000000 hand-soldered joints.

[6] Although mentioned in Woman of the ENIAC at the time, little recognition was attributed to the women working on the computer, with attention focused on the male engineers who built the machine.

This award was established in 1996 by WITI to "recognize, honor, and promote the outstanding contributions women make to the scientific and technological communities that improve and evolve our society".

Her work on ENIAC and at the University of Pennsylvania was later recognized in the 2010 documentary film Top Secret Rosies: The Female "Computers" of WWII.