[2] From 1993 to 2000, she worked at the United States Treasury Department on issues like the 1997 Asian financial crisis and predatory lending.

[2][5] Levine was vice president of global public policy for Facebook from 2010 to 2014,[6] when she became the first chief operating officer of Instagram.

[8] In June 2021, Levine was named chief business officer of Facebook, Inc. which was renamed Meta Platforms.

[10] Levine is a member of the board of Lean In, a non-profit founded by Facebook COO Sheryl Sandberg to empower women.

[1][15][12] Her father-in-law, John M. Deutch, was the director of central intelligence (DCI) during the presidency of Bill Clinton.