He has investigated the use of dynamic ultrasonography to detect sports hernia injuries and is the primary investigator for an ongoing, collaborative research project with the United States Olympic Committee and Henry Ford Hospital, which is evaluating the use of ultrasound to diagnose sports injuries in female hockey players.
He is also a consultant and co-researcher for NASA and the National Space and Biomedical Research Institute (NSBRI) in the Advanced Diagnostic Ultrasound in Microgravity Project, which involves teaching ultrasound to the astronaut and cosmonaut crews of the International Space Station to use for medical emergencies.
This work has been modified for use on the Earth where his team supports the on-site care of professional sports teams and United States Olympic Committee athletes, Summer and Winter Olympic Games, and the Wayne State University School of Medicine.
Van Holsbeeck has received numerous teaching and professional awards including the President's Medal of the International Skeletal Society and the Belgian Radiologic Society.
He has written over 100 peer-reviewed articles, and is the first author for a leading radiology textbook, Musculoskeletal Ultrasound.