He played college football for the USC Trojans, winning the Biletnikoff Award as the nation's top receiver and earning unanimous All-American honors in 2012.

[2] At Serra High School, Lee was a year behind a stand-out wide receiver, Robert Woods, who also went to USC.

[4] As a senior, Lee had had 57 receptions for 1,409 yards and 24 touchdowns as a wide receiver and 45 tackles and three interceptions as a defensive back.

[5][6] A number of major NCAA Division I FBS college football programs offered him athletic scholarships and Lee made official visits to Florida, Miami, and Oregon before choosing to attend USC.

[10] As a true freshman at USC in 2011, he earned a starting job at wide receiver across from his former high school teammate Robert Woods.

[31] Throughout training camp, Lee competed against Ace Sanders and Robinson for the vacant starting wide receiver position that was left open after the suspension of Justin Blackmon.

[34] He made his professional regular season debut and first career start during the Jaguars' season-opener at the Philadelphia Eagles and caught a season-high six passes for 62-yards in their 34–17 loss.

[38] Lee competed against Robinson and Allen Hurns for the vacant starting wide receiver position left by the departure of Shorts.

[39][40] Offensive coordinator Greg Olson named Lee the fourth wide receiver on the depth chart to begin the regular season, behind Robinson, Allen Hurns, and Bryan Walters.

[44] Lee entered training camp competing against Rashad Greene to be the Jaguars' third wide receiver on their depth chart.

[45] Head coach Gus Bradley named him the third wide receiver to begin the regular season behind Robinson and Hurns.

[47] Lee became one of the starting wide receivers for the remainder of the season after Allen Hurns suffered a hamstring injury that sidelined him for the last five games.

[51] He finished his last season under head coach Gus Bradley with 63 receptions for 851 receiving yards and three touchdowns in 16 games and six starts.

[53] Throughout training camp, Lee and Allen Hurns competed to be a starting wide receiver alongside Robinson.

[54] Offensive coordinator Nathaniel Hackett named Lee and Robinson the starting wide receivers to begin the season.

[57] On January 7, 2018, Lee started his first career playoff game and had a five-yard rush and was only targeted once in the Jaguars' 10–3 victory over the Buffalo Bills in the AFC Wild Card Round.

[31][61] On August 25, 2018, in the third preseason game, Lee suffered a severe knee injury and had to undergo season-ending surgery.