Jackson was rated by Rivals.com as a five-star recruit and was ranked as the number one athlete and sixth best player overall in his class.

[13] Jackson placed fifth[14] in the long jump (almost 26 feet) and 4th in the 4×100 meters 2015 NCAA outdoor track and field championship earning two All-American awards.

On November 12, 2016, Jackson intercepted two passes from Washington's quarterback Jake Browning, helping the Trojans win their fifth straight game and upset the fourth-ranked Huskies, who were undefeated at the time.

[29] He competed with Logan Ryan, LeShaun Sims, Brice McCain, and Kalan Reed throughout training camp for the vacant starting cornerback positions after the departure of Jason McCourty and Perrish Cox during the off season.

Head coach Mike Mularkey named him the starting cornerback, opposite Logan Ryan, and punt returner to begin the regular season.

[32][33] In the next game against the Jacksonville Jaguars, Jackson recorded three solo tackles and returned two punts for 55 yards in a 37–16 road victory.

[34] The following week, he collected five combined tackles, defended two passes, and returned five punts for a total of 51 yards in a 33–27 victory over the Seattle Seahawks.

[35] During Week 9, Jackson recorded eight combined tackles, deflected a pass, and had his first NFL carry for a 20-yard gain in a 23–20 win over the Baltimore Ravens.

[36][37] In the next game against the Cincinnati Bengals, he had two tackles and two pass deflections along with 30 rushing yards as the Titans won by a score of 24–20.

The following week, Jackson had 11 tackles, two pass deflections, and a forced fumble along with five rushing yards in a 40–17 road loss to the Pittsburgh Steelers.

[39][40] The Titans finished second in the AFC South with a 9–7 record and made the playoffs as a Wild Card team.

[41][42] In the Wild Card Round against the Kansas City Chiefs, Jackson had four tackles and 61 return yards in the narrow 22–21 road victory.

[52] In Week 16 of the 2023 season against the Philadelphia Eagles, Jackson recorded his first career Pick 6 on pass thrown by Jalen Hurts taking it 76 yards for a touchdown.