Marquinhos made his professional debut for São Paulo on 11 July 2021, coming on as a 78th minute substitute in a 1–0 Série A home win against Bahia.

[6] He made his Premier League debut on 18 September, coming on as a late substitute for Bukayo Saka in a 3–0 win at Brentford.

[9][10] He made his debut on 25 February, scoring once and also providing an assist for Gabriel Sara in Norwich's 2–0 win against Cardiff City.

[11] Marquinhos received the first red card of his senior career on 15 March in Norwich's draw at Huddersfield Town after he appeared to elbow Josh Ruffels.

[12][13] On 12 August 2023, Ligue 1 side Nantes announced the signing of Marquinhos on a season-long loan from Arsenal, with no future option to make the move permanent.