The name of this show refers to the book Men Are from Mars, Women Are from Venus by John Gray.

They are played by, namely: Tay Ping Hui and Huang Biren, Pierre Png and Jesseca Liu, Cavin Soh and May Phua, Chen Tianwen and Aileen Tan.

Their marriage ends up in a divorce with the constant interference from Steven's mother (Li Yin Zhu), who hopes to find a better wife for her son in his ex-girlfriend, Aimei (Le Yao).

Their marriage is further put to test when William gets to know that he is infertile (low sperm count), which would greatly reduce the chances of Ziling getting pregnant.

Carmen had a womanizer rich husband who died, while Hanns's fiancee eloped with another man while they were on honeymoon.

Forty-year-old Yu Lian is the boss of a dessert shop, Yu Lian's Dessert Shop while Ah Wu is a big boss of the Pavi brand shoe company.