It is part of the Marshall Independent School District which serves students in central Harrison County.

The first Marshall High School had only two teachers, who instructed 30 students in five subjects: Latin, English, history, math, and science.

However, due to the rapid growth of both the elementary classes as well as the high school, overcrowding became an issue almost immediately.

MHS was relocated in 1907 to the old Masonic Female Institute campus to alleviate the crowded facility, but also to provide much needed science lab space for the students.

In 1967, the first African American students to integrate were Robert Campbell, who wanted to take advantage of Marshall High's art program, and Herbert Chambers.

A supplemental field house for baseball, cross-country, soccer, and tennis opened at the north end of Maverick Drive in December, 1988.

A major expansion for the MHS band program came in the mid 1990s with a 2nd rehearsal hall, more practice space, a loading dock, and expanded storage.

In the late 1990s MISD constructed what is widely considered one of the finest softball facilities in the state for the Lady Mavs.

MHS competes the following sports: cross country, volleyball, football, basketball, powerlifting, swimming, soccer, golf, tennis, track, baseball, and softball.