[2] In 2009, she became an active member of the PAN, and from 2011 to 2016, coinciding with most of her husband's tenure as governor, she presided over the foundation for the Puebla State DIF System.

She allegedly was picked for the nomination because PAN internal polling showed her as being a stronger candidate than the mayor of Puebla, Eduardo Rivera Pérez.

[5] Alonso won the election, defeating Miguel Barbosa Huerta on the Juntos Haremos Historia coalition ticket and two other candidates, on 1 July 2018, as the first female governor of Puebla and the seventh nationwide.

[6] On 24 December 2018, a helicopter carrying Alonso, Rafael Moreno Valle and other PAN politicians from the state crashed in a field near the town of Santa María Coronango,[7] half an hour from the city of Puebla, killing all.

In a tweet, President Andrés Manuel López Obrador indicated that Alonso and Moreno Valle were on the downed aircraft;[8][9] she had been governor for ten days.