[1] Martha was born in 1505, the daughter of Sir Edmund Denny, Chief Baron of the Exchequer, and Mary Troutbeck.
Her brother was Sir Anthony Denny, a leading member of the Privy Chamber, and a confidant of King Henry VIII of England.
On an unknown date she married Sir Wymond Carew of Antony, Cornwall, by whom she had 16 or 19 children (varying sources), an unknown number of whom survived to adulthood, including: Sir Wymond was the treasurer of King Henry's fourth and sixth wives, Anne of Cleves and Catherine Parr.
As she was unable to pay what was in the 16th century a large sum of money, the manor at Hackney as well as other lands passed to the Crown in 1554.
[3] Following the loss of her home at Hackney, Denny moved to London, where on 8 September 1562, she was arrested for having attended a Roman Catholic mass.