He became Grand Prior of the Order of Malta of Navarra in 1641, and Viceroy of Sicily in 1656.

He was elected Grand Master of the Knights Hospitaller in 1657 after the death of Giovanni Paolo Lascaris.

During his rule, he commissioned the building of 13 de Redin watch towers around the coast of Malta.

These towers created a line of communication around the island to give warning of the approach of corsairs and pirates.

De Redin also created a corps of 4,000 musketeers, and brought in food and supplies from Sicily when Malta suffered a shortage during his reign.