[4][5] Prior to the release of the first issue, Newsarama published a preview,[6] revealing the birth of the zombified Avengers, Ash's descent into the Marvel Zombie universe, and the infection of Spider-Man.

The superpowered entity known as The Sentry shows up in the afterlife (having been sent there by the Watcher in Marvel Zombies Return) and begins consuming everyone in sight.

He mistakes Daredevil for the villain, and after letting Thunderball escape, tries to warn the Avengers of a Deadite invasion.

(In the prequel comic Marvel Zombies: Dead Days, it is revealed that Spider-Man is eventually 'consumed' by the zombification disease and kills and devours his loved ones.)

Since there is no Necronomicon in the mansion, the trio travel to Latveria, the castle of Doctor Doom, which is under attack by an invasion force (from Dead Days, where Reed Richards turned his Fantastic Four into zombies upon deciding this infection is the most efficient form of life).

The zombies break into the castle; Scarlet Witch is attacked and infected by the zombified Punisher, and Doom is bitten and infected by Reed Richards, but manages to escape and fight back the disease to aid his people's escape to an alternate universe.

The book reveals that yes, an "army of the dead will rise" and yes, the world will fall, but that those two things don't necessarily have anything to do with each other, apart from happening around the same time.

In each, Ash is spliced in alongside zombified characters or replacing a character on the original cover (i.e. Bucky) The series has been collected into one volume: The "Werewolf Spider-Man" introduced during the closing moments of the series made his cinematic debut in the 2023 feature film Spider-Man: Across the Spider-Verse, depicted as a member of Miguel O'Hara's Spider-Society.