Neuroscience Mary-Frances O'Connor is an American psychologist who is a professor of psychology at the University of Arizona,[1] where she directs the Grief, Loss, and Social Stress (GLASS) Lab.

"[4] Learning is required to update the brain's prediction that the loved one will always be there, to the reality that they are truly gone, or the gone-but-also-everlasting hypothesis developed by O'Connor.

[7] Her research focuses on the neurobiological grief response to loss with function neuroimaging, cognitive tasks, and clinical interviews.

[9] Under her leadership, the group has held four international conferences, with initial support provided by the National Institute on Aging.

[10] O'Connor's book The Grieving Brain: The Surprising Science of How We Learn from Love and Loss was published in 2022[16] and has received praise from peers and literary critics.