At her home in Springfield she had a fully equipped laboratory where she prepared and stored microscope slides.

Booth travelled extensively around the United States and Canada, and was interested in photography.

She prepared the micrographs used by Rupert Blue during his efforts to stop bubonic plague in San Francisco.

[4][5] Noted for her preparation of diatoms and pollens, Booth earned a Diploma of Honor in Entomology (Women's Department) at the 1884–85 New Orleans World's Industrial and Cotton Centennial Exposition.

[7] Whilst suffering from an illness at her home, Booth acquired skills in preparing slides for microscopy for a variety of human parasites, and was considered to have the largest private collection of them.