Mary Ann in Autumn (2010) is the eighth book in the Tales of the City series by San Francisco novelist Armistead Maupin.

Mary Ann Singleton, now in her late fifties,[1] returns from New York City with a reason to seek support and a secret that she needs to share with Michael 'Mouse' Tolliver.

Mary Ann Singleton Carruthers flees her luxurious life in Darien, Connecticut for San Francisco, seeking solace from old friend Michael Tolliver.

Meanwhile, other former Barbary Lane residents show up in the novel: Mary Ann's adoptive daughter Shawna is a popular sex blogger and is dating Otto, a clown;[2] Anna Madrigal has mostly recovered from the stroke she had in Michael Tolliver Lives; Michael's assistant, Jake Greenleaf, wrestles with his attraction to a closeted Mormon missionary who is involved in the movement to "cure" homosexuals; and Jake, a trans man, despairs of ever saving enough money to pay for surgery.

As the novel progresses, Dede and D'Orothea show up to help Mary Ann with her recuperation, Shawna befriends a homeless junkie prostitute, Jake makes a startling discovery, and a threat from the past comes back to haunt the former Barbary Lane residents.