Her 1770 diary provides an early account of smallpox inoculation in colonial America.

Edward Ambler was a graduate of Cambridge University who was six feet tall and fond of wearing red velvet suits trimmed with gold lace.

In her diary, Ambler wrote about the process, the details of their meals and travel, and her appreciation for her Baltimore landlady's library, especially Sermons to Young Women.

[1][2][3][8] During the American Revolutionary War, Ambler decamped further inland for Hanford County, Virginia, renting her Jamestown property to a Captain Edward Travis.

[5] Mary Cary is sometimes said to have been a love interest of a young George Washington, but this is due to confusion with her elder sister, Sally Fairfax.