Booth was born Mary Devlin in Troy, New York, on May 19, 1840.

[2][1] She married Edwin Booth on July 7, 1860, at which point she retired from acting.

[3] She is buried at Mount Auburn Cemetery in Cambridge, Massachusetts beside her daughter and husband.

[5] In 1860, Booth appeared as Juliet in a production of Romeo and Juliet, alongside actress Charlotte Cushman, who played Romeo.

[3] Booth was portrayed by actress Maggie McNamara in the 1955 film Prince of Players.