Mary Ellen Weber (born August 24, 1962) is an American executive, scientist, aviator, and a former NASA astronaut.

[5] At Texas Instruments she researched new processes and revolutionary equipment for making computer chips, with SEMATECH and Applied Materials.

She worked extensively in technology commercialization, and as part of a team reporting to NASA's chief executive, she worked directly with a venture capital firm to successfully identify and develop a business venture leveraging a space technology.

Prior to this appointment, she was chairman of the procurement board for the Biotechnology Program contractor,[9] and she also served on a team that revamped the $2 billion plan for Space Station research facilities.

The crew repaired and installed electrical and life-support components, both inside and out, and boosted the Station to a safe orbit.

Weber was a flight deck crew member for launch, landing and Station rendezvous, drove Atlantis' 60-foot robotic arm to maneuver spacewalk crewmembers along the Station surface, and directed the logistics and transfer of over three thousand pounds of equipment.

She also developed new crew checklists for engine failures during ascent and new procedures for robotic arm operations.