MaryLouise Isaacson (born November 15, 1970) is an American politician serving as a member of the Pennsylvania House of Representatives from the 175th district since 2019.

In 1990, Isaacson received her Associate degree in early childhood development from State University of New York at Farmingdale.

[1] From 2006 to 2018, Isaacson served as chief of staff to Pennsylvania State Representative Michael H. O'Brien.

Isaacson also served on the Democratic State Committee of Pennsylvania starting in 2010.

[1] Because of health issues, O'Brien filed paper work to remove his name from the 2018 general election ballot.